| Instant Web | George | Software Development, hosting, domain registry | |
| Institute for Healing of Memories | Cape Town | Mental Health Services | |
| Intelligent Debt Management | Cape Town | Debt Management | |
| Intellisec | Cape Town | Security Systems | |
| InTempo Trailer Manufacturers | Cape Town | Manufacturing Trailers Repairs Upgrades Conversion | |
| Interactivemedia | Cape Town | It & Digital signage | |
| Intercon Recruitment | Cape Town | Recruitment Agency, | |
| Interglobe Outsourcing | Cape Town | Labour hire | |
| INTERNATIONAL COMPUTER DRIVING LICENCE (ICDL SA) | Cape Town | To promote digital literacy to all. | |
| International Hotel School | Cape Town | Hospitality & Culinary Education Provider | |
| Into the light films | Cape Town | Video Production | |
| Intrawit | Hermanus | Hosting and Design | |
| InvestmentWise | Cape Town | Financial Wellness Training | |
| InvestToRent.com | Cape Town | A blockchain platform for property | |
| Involved Digital | Cape Town | Website Design and Development | |
| Ipic Media | Cape Town | Graphic Design | |
| IronTree | Cape Town | Provider of cloud based, online backup solutions | |
| Iseli Energy | Cape Town | Business to Business | |
| Isle of trees 'Naturally Creative Design' | Cape Town | Direct Marketing | |
| Isoflow | Cape Town | UX & UI Design | |
| IT Clarity | Bellville | Business Intelligence and document management | |
| IT SELECT - StaffSelect | Cape Town | HR Advisory Talent Acquisition - IT | |
| Italina Ovens | | Supply Home Wood Burning Portable Pizza Ovens | |
| Itblue Solutions | Stellenbosch | Reliable and Preferred IT Partner | |
| ITClarity | Bellville | Document management | |
| ITM Website Design | Cape Town | Website Design SEO and Digital marketing | |
| Ivie Media | Cape Town | Specialising in broadcast, out-of-home advertising | |
| Ixande Addiction and Psychiatric Care Center | Cape Town | Ixande Addiction and Psychiatric Care Center | |
| Izelle Labuschagne Photography | Cape Town | Content creation, Social Media, Photography | |
| Izembatho Creations | Cape Town | Fashion Designing | |
| iZZi Hotels | Cape Town | Hotel Management & Marketing | |
| J.J.A.D Marine & Industrial Installations | Cape Town | Piping Solutions, HDPE Piping, Water Purification | |
| Jabu Msomi Location Sound and Camera | Cape Town | Film/TV Broadcast Location Sound Recordists + Gear | |
| Jackie Lagus Copywriter | Cape Town | Journalism & PR | |
| Jacobs Evolution | CAPE TOWN | FROZEN WORLD | |
| JaCServDelivery | Cape Town | Courier/Logistics/Deliveries/Collection/Transport | |
| JAG Method | Cape Town | Digital marketing | |
| JAGGER PROMOTIONS | Cape Town | Printing and embroidery of promotional items | |
| Jajaofafrica Marketing and Comm | Cape Town | creative solutions | |
| Jamela Africa Safaris | Cape Town | inbound FIT international clientele | |
| Jane Field Makeup & Tattoo Artist | Cape Town | Makeup and Tattoos | |
| Jane Says | Cape Town | 1990 | |
| Jansen Accountants and Auditors Inc | Cape Town | Accounting, tax and auditing | |
| JaxLahoud Media Consultant & Strategist | Cape Town | Winemag (Pty) Ltd | |
| JBS Energy Solutions | George | Battery Sales, Repacking & Design, Chargers | |
| JC Media Puzzles | Lotus River | Photo jigsaw puzzle invitation manufacturers | |
| JCP Hotelware | Cape Town | Contract Purchasing/Supply/Procurement | |
| Jekyll and Hide | Cape Town | Selling online | |
| Jenna Business Systems | Oudtshoorn | Cash Registers Business Software Management | |
| Jerne | Cape Town | Leather Bag Crafting and Sales | |
| Jessica Ellen | Cape Town | Portrait and wedding photography and design | |
| Jet Fuel Digital | Cape Town | Digital Marketing | |
| Jetline Green Point | Cape Town | Digital and Litho Printing | |
| JetSet-Go Travel | Bellville | Travel Agency | |
| Jewel Consultants | Durbanville | Telecommunications, CCTV, IT Services, VOIP, Inter | |
| JG ELECTRONICS | Cape Town | Sublimation Heat Transfer Printing - 011-789-6033 | |
| JJ Sound and Screen | Cape Town | Sales, Maintenance & Rentals | |
| JKB Consultancy | Cape Town | Empowering Global Citizens through Technology | |
| JL Joiners & Shopfitters | Cape Town | Joinery and Shopfitting | |
| JLM Property | Cape Town | Property Management | |
| JLM Tax Solutions | Cape Town | Accountant | |
| JLP Consultants & Rapporteurs | Cape Town | Scribing/rapporteuring/minutes/editing | |
| jnm Auto Glass | kuilsriver | Mobile Auto Glass Repair | |
| JNZ Group | Cape Town | Software Development | |
| Joffe Financial Services | Cape Town | Financial Advice/Planning | |
| Johann Lourens Photography | Cape Town | Architectural & Interior Design Photography | |
| John Binns Marketing | Table View | Strategic Business Development | |
| John Frank Apparel | Cape Town | Niche swimwear , tshirts and accesories | |
| Johnson3 Global Consulting | Mouille Point | Consulting | |
| Johnson3 Global Consulting | Mouille Point | General PR/Marketing/Social Media/Promotions | |
| Jonathan Ball Publishers | Cape Town | Publisher/Distributor of books | |
| Jonathan Misnuner Video Production | Cape Town | Wedding/Function Videos | |
| Joren Communications | Cape Town | Web Development | |
| Journey To Health | Hout Bay | Health Shop | |
| Joy Sky Logistics | Cape Town | Logistics & Transport | |
| JP inc. Communications | Cape Town | Public Relations and Marketing Communications | |
| Julian Goldswain Photography | Cape Town | Commercial Lifestyle Photography | |
| June16 Events | Cape Town | Events, advertising and marketing, CSI projects | |
| JuneDay | Knynsa | Digital Marketing | |
| Jungle Mania Structures | Cape Town | install jungle gyms and playground equipment | |
| Jurgen Productions | Cape Town | Social media Marketing, web designing, more... | |
| Juro Trading | Cape Town | Below the line advertising and trading company | |
| Just Medical | Cape Town | Medical Supplies | |
| Just Pointblank | Cape Town | website design, animation, branding, SEO | |
| Just Pure Natural Products | Hermanus | Beauty product supplier | |
| Justin Ketle | Cape Town | None | |
| K&i | Cape Town | Branding, Graphic design, Website design | |
| K2 Accounting | | Accounting and Tax advisory | |
| Ka Matjeke Advertising | | Advertising | |
| Ka-Ching! | Cape Town | Financial education,Entrepreneurship, | |
| Kaarm Building Services | Cape Town | Waterproofing, drywall Partitioning, painting | |
| Kadence Blue HR | Cape Town | HR Consulting, Advisory, Training & Support | |
| Kadence Blue HR Consultants | Cape Town | HR Audits, HR Projects, Culture & Engagement | |
| Kaleidoscope NeuroMarketing & Advertising Agency | Cape Town | NeuroMarketing, Email Marketing, Web Design | |
| KAN Screenprinters | Cape Town | Screenprinting, pad printing, laser engraving | |
| Kangela Digital | Mossel Bay | Digital Marketing | |
